Nanoparticles in medicine usually accumulate in one organ of the body or another except the brain(due to the blood-brain barrier). Even if the particles are encapsulated in a biocompatible polymer such as PEG, the only parameter affected is the blood stability time of the nanoparticles.
The most common organ of deposition is the liver and spleen, although the heart and lung tissue are major contenders also. Particles if size range 500-1000 nm tend to accumulate in the lungs and kidneys and the specific reaction to such particles depends on the metal composition and the encapsulating polymer.
Particles of lower size range(10-200 nm) accumulate preferentially in the liver and spleen. Even if the accumulated particles are benign, saturation causes necrosis of tissue. I recently read about distribution of gold nanorods in mice. Saturation of nanorods in the liver caused necrosis of liver tissue after dosage of 0.3 micrograms over a period of four weeks.
While particles of higher size range are evacuated after a week of ingestion, the smaller particles are permanently trapped in the body tissue.
Reference: https://www.quora.com/How-are-nanoparticles-used-in-nanomedicine-removed-from-the-body
The most common organ of deposition is the liver and spleen, although the heart and lung tissue are major contenders also. Particles if size range 500-1000 nm tend to accumulate in the lungs and kidneys and the specific reaction to such particles depends on the metal composition and the encapsulating polymer.
Particles of lower size range(10-200 nm) accumulate preferentially in the liver and spleen. Even if the accumulated particles are benign, saturation causes necrosis of tissue. I recently read about distribution of gold nanorods in mice. Saturation of nanorods in the liver caused necrosis of liver tissue after dosage of 0.3 micrograms over a period of four weeks.
While particles of higher size range are evacuated after a week of ingestion, the smaller particles are permanently trapped in the body tissue.
Reference: https://www.quora.com/How-are-nanoparticles-used-in-nanomedicine-removed-from-the-body
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